這次的靈魂交換加倍升級，安娜的女兒與繼女也進入變身圈，晉級為一場四人靈魂交換的情境。預告片中酷兒公主（Chappell Roan）的〈Hot To Go! 〉配樂更展輕鬆詼諧。除了兩位女主角，原班人馬包括馬克漢蒙、查德莫瑞與他的秀髮都強勢回歸。
演員: 琳賽·蘿涵
/ Jamie Lee Curtis
/ Julia Butters
/ Sophia Hammons
/ Mark Harmon
/ Manny Jacinto
/ 麥崔伊·拉曼克莉希南
/ Christina Vidal
/ Haley Hudson
/ Chad Michael Murray
/ X Mayo
/ Lucille Soong
/ 趙家玲
/ Vanessa Bayer
/ Jordan E. Cooper
/ June Diane Raphael
/ Mary Sohn
/ Santina Muha
/ Stephen Tobolowsky
/ 阿里安·西姆德里
/ George Wallace
/ Sherry Cola
/ Kylah Davila
/ Nell Murphy
/ Noen Perez
/ Ryan Malgarini
/ Valentina Garcia
/ Jimmy Bellinger
/ Ahmed Bharoocha
/ David Miranda
/ Helena Grace Donald
/ Steve Crystal
/ Chloe Fineman
/ Elaine Hendrix
/ Kiran Deol
/ Venk Modur
/ Reasha Honaker
/ Danielle Bux
/ Jaden Carson Baker
/ Jai Ganatra
/ Eli Wolfensohn
/ Micah Wolfensohn
/ A.J. Danna
/ Emiliana Gavoni
/ Julien Worsham
/ Naomi Fogarty
/ Neel Mathoda-Shahi
/ Katherine Curcio
/ Aracely ORtiz
/ Kimberly Bigsby
/ Bruce Seymour
/ Akshya
/ Jonathan Rabon
/ China Taylor
/ Cedric Reboya
/ Ricky Munoz
/ Monique Watson
/ Chloe Mihacevich
/ Luz Celeste Remigo-Frias
/ Chris Carlberg
/ Danny Rubin
/ Naomi McPherson
/ Katie Gavin
/ Josette Maskin
/ Suzy Shinn
/ Max Kuehun
/ Fiora Cutler
/ Stephanie Yu
/ Darla Hawn
/ Amir Derakh
